I was going to say that if you don't install/uninstall the Adobe Flash plug-in you will avoid much of the annoying crap. Unfortunately I notice that you also won't be able to add any strips to your favourites list, unless I'm missing some alternative method. Checked out the /fast version and can't see anything there either.
What I also miss in the new site is the drop down list of the other comics available, although I think I had it disabled much of the time anyway as I'm using Firefox with the NoScript add-on which disables all Javascript associated with a webpage and you have to re-enable on a script by script basis and I was never certain which script was for the dropdown box and which were just for annoying pop ups (sorry, "interstitials").